Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Combined diffusion weighting and CSF suppression in functional MRI.

Linda Andersson1, Max Bolling, Ronnie Wirestam

  • 1Department of Radiation Physics, Lund University Hospital, Sweden. Linda.Andersson@radfys.lu.se

NMR in Biomedicine
|April 23, 2002
PubMed
Summary

New functional MRI techniques, inversion recovery echo-planar imaging (IR-EPI) and diffusion-weighted IR-EPI, reduce false BOLD signal activation from CSF pulsations and large vessels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-associated B-cells predict coronary events in humans and aggravate murine atherosclerosis.

Cardiovascular research·2026
Same author

Concomitant Gradient Effects Across Field Strengths and Gradient Amplitudes: Improved Estimation of Errors and Correction of Concomitant Dephasing and Diffusion Weighting.

Magnetic resonance in medicine·2026
Same author

Angiopoietin-like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride-rich lipoproteins in humans.

Journal of internal medicine·2026
Same author

Association between body weight and hip dysplasia screening results in young adult dogs of different breeds in Sweden.

Scientific reports·2026
Same author

Deletion of PKM2 in Macrophages Promotes Stabilization but Not Regression of Atherosclerotic Plaques.

Circulation research·2026
Same author

Toward Super-Resolution Reconstruction of Diffusion-Relaxation MRI Using Slice Excitation With Random Overlap (SERO).

Magnetic resonance in medicine·2026

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Functional MRI (fMRI)

Background:

  • Blood-Oxygen-Level-Dependent (BOLD) contrast is crucial for functional MRI (fMRI).
  • Standard gradient-echo EPI sequences are susceptible to artifacts from cerebrospinal fluid (CSF) pulsations and large blood vessels.
  • These artifacts can lead to inaccurate localization and quantification of brain activity.

Purpose of the Study:

  • To develop and evaluate novel EPI pulse sequences for BOLD fMRI.
  • To reduce artifacts caused by CSF pulsations and large vessels.
  • To improve the accuracy of BOLD signal detection in functional neuroimaging.

Main Methods:

  • Developed two new pulse sequences: inversion recovery echo-planar imaging (IR-EPI) and diffusion-weighted IR-EPI (DW-IR-EPI).

Related Experiment Videos

  • Compared these sequences against a standard gradient-echo EPI sequence in a motor cortex stimulation experiment in nine healthy volunteers.
  • Activated volume and relative signal increase were measured, with artificial noise added to equalize signal-to-noise ratios (S/N) for fair comparison.

    • Main Results:

    • DW-IR-EPI significantly reduced activated volume compared to standard EPI (15 +/- 13 vs. 128 +/- 73 pixels).
    • IR-EPI also showed reduced activated volume (31 +/- 12 pixels) and higher signal increase (11.5 +/- 3.1%) than standard EPI (5.7 +/- 1.1%).
    • At equal S/N, IR-EPI demonstrated a higher signal increase (12.0 +/- 3.6%) compared to standard EPI (7.3 +/- 1.4%), with a reduced activated volume (28 +/- 13 pixels).

    Conclusions:

    • The combination of diffusion weighting and inversion recovery effectively minimizes false BOLD activation.
    • These advanced pulse sequences offer improved specificity and accuracy in functional MRI studies.
    • The developed techniques are valuable for precise BOLD contrast investigations, reducing confounds from physiological noise.