[The 50-year history of PAS production at Tanabe Seiyaku]

More than 50 years have passed since Tanabe Seiyaku Co., Ltd. (Tanabe) started producing PAS series (para-aminosalicy-late), which is one of the typical antituberculous agents. NIPPAS series, Tanabe's PAS was produced by the enormous efforts of Tanabe's researchers and engineers in the 1950s, and it made a great contribution to the remedy for many tuberculars. After that, the prominent progress of antituberculous agents, medical technology, and public hygiene dramatically decreased the member of tubercular patients, and usage of the PAS series was also on the decrease year by year. Most recently, tuberculars are unfortunately increasing gradually and the NIP-PAS series holds an important position as a prominent remedy for this disease. Therefore Tanabe still produces NIPPAS. This paper describes the historical process of NIPPAS production of Tanabe.