[Recent advances in molecular pathogenesis of HIV infection]
1Institute for Virus Research, Kyoto University.
Highly active anti-retroviral therapy (HAART) dramatically improves the prognosis of individuals infected with HIV, and changes the pathophysiology of HIV infection. However, the eradication of HIV has not been achieved by HAART due to presence of reservoir cells. More potent strategy of therapy against HIV is needed for further suppression of the replication and eradication of reservoirs. The recent advances about molecular pathogenesis of HIV infection are reviewed in this paper, that leads to discovery of the new molecular targets of anti-HIV drugs.
Highly active anti-retroviral therapy (HAART) dramatically improves the prognosis of individuals infected with HIV, and changes the pathophysiology of HIV infection. However, the eradication of HIV has not been achieved by HAART due to presence of reservoir cells. More potent strategy of therapy against HIV is needed for further suppression of the replication and eradication of reservoirs. The recent advances about molecular pathogenesis of HIV infection are reviewed in this paper, that leads to discovery of the new molecular targets of anti-HIV drugs.
