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[Genetically engineered mice and its application to bioindustry].

Toshiaki Koda1, Yuji Togashi, Takashi Nishimura

  • 1Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.

[Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
|April 24, 2002
PubMed
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The creation of transgenic mice has advanced significantly over two decades, with gene targeting and conditional systems enabling new possibilities. These genetically engineered mice are crucial for disease modeling and biological research, presenting opportunities for bioindustry.

Area of Science:

  • Genetics and Genomics
  • Molecular Biology
  • Bioengineering

Context:

  • The development of transgenic mouse technology has spanned over 20 years.
  • Gene targeting represents a pivotal advancement in genetic engineering.
  • Conditional gene targeting, utilizing the Cre/loxP system, has refined mouse model generation.

Purpose:

  • To review recent technologies in mouse genetic engineering.
  • To explore the applications of these technologies in the bioindustry.
  • To highlight the importance of mutant mice for research and disease modeling.

Summary:

  • This review details advancements in mouse genetic engineering, focusing on gene targeting and conditional systems.
  • It discusses the creation of mutant mice for applications in disease modeling and fundamental biological research.

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  • The integration of these technologies offers significant potential for the bioindustry.

    • Impact:

    • Facilitates the development of sophisticated animal models for human diseases.
    • Provides essential resources for basic biological research.
    • Creates commercial opportunities within the bioindustry for specialized mouse models.