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Updated: Jul 7, 2026
12:04
Mouse Genome Engineering Using Designer Nucleases
Published on: April 2, 2014
[Genetically engineered mice and its application to bioindustry]
Toshiaki Koda1, Yuji Togashi, Takashi Nishimura
1Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
[Hokkaido Igaku Zasshi] the Hokkaido Journal of Medical Science
|April 24, 2002
Summary
The creation of transgenic mice has advanced significantly over two decades, with gene targeting and conditional systems enabling new possibilities. These genetically engineered mice are crucial for disease modeling and biological research, presenting opportunities for bioindustry.
Area of Science:
- Genetics and Genomics
- Molecular Biology
- Bioengineering
Context:
- The development of transgenic mouse technology has spanned over 20 years.
- Gene targeting represents a pivotal advancement in genetic engineering.
- Conditional gene targeting, utilizing the Cre/loxP system, has refined mouse model generation.
Purpose:
- To review recent technologies in mouse genetic engineering.
- To explore the applications of these technologies in the bioindustry.
- To highlight the importance of mutant mice for research and disease modeling.
Summary:
- This review details advancements in mouse genetic engineering, focusing on gene targeting and conditional systems.
- It discusses the creation of mutant mice for applications in disease modeling and fundamental biological research.
- The integration of these technologies offers significant potential for the bioindustry.
Impact:
- Facilitates the development of sophisticated animal models for human diseases.
- Provides essential resources for basic biological research.
- Creates commercial opportunities within the bioindustry for specialized mouse models.
Related Concept Videos
00:49What is Genetic Engineering?
Overview
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...