Related Experiment Videos
Why FRET about Ran?
1Center for Cell Signaling, and Department of Pharmacology, Box 800577, HSC, University of Virginia, Charlottesville, VA 22908, USA.
Developmental Cell
|April 24, 2002
Abstract:
The Ran GTPase drives nucleocytoplasmic transport, stabilizes mitotic spindles, and catalyzes nuclear envelope formation. A unifying explanation of these functions is that RanGTP produces an organizing field or "atmosphere" around chromatin and acts as a spatial marker. This RanGTP field has now been visualized using fluorescent biosensors.