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Related Experiment Videos

Quantitative functional measures in MS: what is a reliable change?

S R Schwid1, A D Goodman, M P McDermott

  • 1Department of Neurology, University of Rochester Medical Center, NY, USA. Steven_Schwid@urmc.rochester.edu

Neurology
|April 24, 2002
PubMed
Summary

This study establishes a 20% change threshold for key functional tests in multiple sclerosis (MS) patients. This reliably indicates true functional changes, aiding in treatment assessment for stable patients.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Measurement

Background:

  • Assessing meaningful functional changes in multiple sclerosis (MS) is crucial for patient management.
  • Quantitative functional tests are used, but their reliability and variability require definition.

Purpose of the Study:

  • To determine the reliability of quantitative functional tests in clinically stable MS patients.
  • To establish a threshold for meaningful change in functional test scores.

Main Methods:

  • Reliability of functional tests was assessed over 5 consecutive days.
  • 63 patients with MS participated in the study.
  • Tests included Time to Walk 25 feet (T25FW) and 9-Hole Peg Test (9HPT).

Main Results:

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  • T25FW and 9HPT scores varied by less than 20% of individual mean scores upon repeated testing in stable MS patients.
  • This indicates a low degree of measurement variability within a short timeframe.

Conclusions:

  • A 20% change in T25FW and 9HPT scores can be considered a reliable indicator of true functional change in individuals with MS.
  • This threshold aids in distinguishing genuine functional decline or improvement from measurement error.