[Role of nitric oxide in the reflex of raising biliary pressure]

Raising the biliary tract pressure from the baseline to 4 kPa significantly decreases arterial blood pressure and myoelectric activity of sphincter of Oddi (SO) (bile duct-arterial blood pressure reflex), which is sometimes associated with the disappearance of phasic myoelectric activity of SO (bile duct-SO reflex). Thirty-two rabbits were used to investigate the role of nitric oxide (NO) in these reflexes. On the base of increased myoelectric activity and arterial blood pressure by intravenous drip of 4 microgram/(kg.min) noradrenaline, raising the biliary tract pressure from the baseline to 4 kPa significantly decreased arterial blood pressure and myoelectric activity of SO. On the base of increased myoelectric activity and arterial blood pressure by intravenous injection of 10 mg/kg L-NNA, the bile duct-arterial blood pressure reflex disappeared in all the rabbits, but the bile duct-SO reflex disappeared only in a population of (3/8) and obviously decreased in the remaining ones (5/8) during raising biliary pressure from the baseline to 4 kPa. The bile duct-SO reflex after preceding local perfusion of L-NNA was similar to that after preceding intravenous injection of L-NNA, but bile duct-arterial blood pressure reflex still appeared. These findings suggest that both of these two reflexes are caused by the tension stimulation to the receptive area of the biliary tract, and may be mediated by NO.