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High serum insulin-like growth factor binding protein-1 is associated with increased cardiovascular mortality in
M Harrela1, Q Qiao, R Koistinen
1Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. maija.harrela@hus.fi
Insights
High levels of Insulin-like growth factor binding protein-1 (IGFBP-1) are linked to increased cardiovascular mortality in elderly men. This study found a significant association between elevated IGFBP-1 and higher risks of death from all causes, cardiovascular disease, and coronary heart disease.
Area of Science:
- Cardiovascular Research
- Endocrinology
- Gerontology
Background:
- Insulin-like growth factor binding protein-1 (IGFBP-1) is a key regulator of IGF bioavailability.
- Previous research suggests IGFBP-1's involvement in cardiovascular disease development.
- The direct relationship between IGFBP-1 and cardiovascular mortality remained unclear.
Purpose of the Study:
- To investigate the association between circulating IGFBP-1 levels and mortality from coronary heart disease, cardiovascular disease, and all causes.
- To determine if IGFBP-1 is a predictive biomarker for cardiovascular mortality in elderly men.
Main Methods:
- A cohort study of 622 men aged 65-84 years, with baseline measurements in 1984.
- Fasting serum IGFBP-1 and other risk factors were measured in 1984 and 1989.
- Cardiovascular events and mortality were tracked from 1984 to 1995, with central coding of diagnoses.
Main Results:
- High fasting serum IGFBP-1 (> 75th percentile) in 1984 was associated with increased five-year total mortality (OR 2.05), cardiovascular mortality (OR 2.20), and coronary heart disease mortality (OR 2.29).
- These associations remained significant after adjusting for age.
- Elevated IGFBP-1 concentrations indicated a higher risk for total mortality (OR 1.73), cardiovascular mortality (OR 1.91), and coronary heart disease mortality (OR 2.02).
Conclusions:
- High fasting serum IGFBP-1 is a significant risk factor for increased five-year total and cardiovascular mortality in elderly men.
- Circulating IGFBP-1 may serve as a potential biomarker for cardiovascular risk stratification in older populations.
- Further research is warranted to elucidate the underlying mechanisms linking IGFBP-1 to cardiovascular outcomes.
Abstract:
Insulin-like growth factor binding protein-1 (IGFBP-1) has been implicated in the development of cardiovascular disease, but it is not known whether IGFBP-1 is related to cardiovascular mortality. We examined the relation of circulating IGFBP-1 to death from coronary heart disease, cardiovascular disease, and all causes in a cohort study consisting of 622 men aged 65 - 84 years, at baseline in 1984. Fasting serum IGFBP-1 and other risk factors were measured in 1984 and 1989. Cardiovascular events for those who died between 1984 and 1995 were analyzed, and cardiovascular diagnoses were coded centrally according to standardized procedures. Of the 622 men, 358 died between 1984 and 1995; 160 deaths were due to cardiovascular causes, 113 of which were coronary deaths. High fasting serum IGFBP-1 concentration (> 75 percentile) in 1984 was associated with increased five-year total mortality (OR 2.05, 95 % CI 1.41 - 2.99; p < 0.0002), cardiovascular mortality (OR 2.20, 95 % CI 1.37 - 3.50; p < 0.0009) and coronary heart disease mortality (OR 2.29, 95 % CI 1.35 - 3.88; p < 0.002). After adjustment for age, high serum IGFBP-1 concentrations still carried an increased risk of total mortality due to (OR 1.73, 95 % CI 1.16 - 2.59; p < 0.007), cardiovascular (OR 1.91 95 % CI 1.18 - 3.09; p < 0.008) and coronary heart disease (OR 2.02. 95 % CI 1.18 - 3.47; p < 0.01). In conclusion, high fasting serum IGFBP-1 is related to increased five-year total and cardiovascular mortality in elderly men.