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Flow cytometric analysis of T cell receptor signal transduction

Traci Zell1, Marc K Jenkins

  • 1University of Minnesota, Department of Microbiology, Room 6-220, Basic Sciences and Biomedical Engineering, 312 Church Street, SE, Minneapolis, MN 55455, USA. zellx001@gold.tc.umn.edu

Science'S STKE : Signal Transduction Knowledge Environment
|April 25, 2002
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Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...