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Online genomics facilities in the new millennium
Dmitrij Frishman1, Andreas Kaps, Hans-Werner Mewes
1Institute for Bioinformatics, GSF - National Research Center for Environment and Heatlh, Ingolstädter Landstrasse 1, 85764 Neueherberg, Germany. d.frishman@gsf.de
Pharmacogenomics
|April 26, 2002
Summary
This review explores biological databases, focusing on the evolution of the yeast genome database into a comprehensive knowledge base. It highlights community curation and data integration for future genomic resources.
Area of Science:
- Bioinformatics
- Genomics
- Database Management
Background:
- Overview of diverse biological databases available online.
- Introduction to the evolution of genomic data resources.
- Importance of specialized databases in biological research.
Purpose of the Study:
- To classify and exemplify key biological databases.
- To detail the transformation of a yeast genome database into a knowledge hub.
- To emphasize the significance of community involvement and data integration.
Main Methods:
- Typological analysis of biological databases.
- Case study of the yeast genome database at MIPS.
- Discussion of community curation and data interoperability.
Main Results:
- Categorization of influential biological databases.
- Demonstration of a genomic resource's evolution from sequence repository to knowledge base.
- Identification of community curation and data integration as critical factors.
Conclusions:
- Biological databases are diverse and evolving resources.
- Community efforts and data integration are essential for advancing genomic facilities.
- The MIPS yeast genome database serves as a model for multidomain knowledge bases.