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Pathogenesis of colonic diverticula.

J Simpson1, J H Scholefield, R C Spiller

  • 1Departments of Surgery and Gastroenterology, University Hospital, Nottingham, UK. j.simpson@nottingham.ac.uk

The British Journal of Surgery
|April 26, 2002
PubMed
Summary

Colonic diverticula, or herniations, may develop due to colon wall weakness or pressure changes. Evidence suggests a low-residue diet is a primary factor in their development.

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Area of Science:

  • Gastroenterology
  • Colorectal Health
  • Digestive System Pathophysiology

Background:

  • Diverticula are herniations through the colonic wall.
  • Pathogenesis is linked to colonic wall weakness, altered intracolonic pressures, or both.
  • This review examines these factors in the development of colonic diverticula.

Purpose of the Study:

  • To review the pathogenesis of colonic diverticula.
  • To explore the relationship between colonic structure, motility, and dietary factors.
  • To synthesize current theories on diverticula development.

Main Methods:

  • Comprehensive literature search of Medline and Science Citation Index.
  • Inclusion of English language articles on colonic diverticulosis pathogenesis since 1960.
  • Manual cross-referencing and inclusion of historical articles.

Main Results:

  • Multiple theories explain the development of colonic diverticula.
  • Morphological changes are largely attributed to lifelong low-residue diet consumption.
  • Complex interactions exist between colonic structure, motility, and diet.

Conclusions:

  • The development of colonic diverticula is multifactorial.
  • Low-residue diet is a significant contributing factor.
  • Genetic influences may also play a role in pathogenesis.

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