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Correction of hyperopia with intracorneal implants.

Mahmoud M Ismail1

  • 1University of Al-Azhar, Cairo, Egypt.

Journal of Cataract and Refractive Surgery
|April 26, 2002
PubMed
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Intracorneal hydrogel lenses show promise for correcting hyperopia in rabbits, demonstrating good tissue compatibility and safety over six months. Further human studies are needed to confirm efficacy and safety in clinical practice.

Area of Science:

  • Ophthalmology
  • Biomaterials Science

Background:

  • Hyperopia correction remains a significant challenge in refractive surgery.
  • Intracorneal lenses offer a potential alternative to traditional refractive procedures.

Purpose of the Study:

  • To assess the safety and efficacy of intracorneal hydrogel lenses for hyperopia correction.
  • To evaluate the biocompatibility of these lenses with corneal tissue in an animal model.

Main Methods:

  • PermaVision hydrogel lenses were implanted in 20 rabbits' eyes using a microkeratome to create a corneal flap.
  • The study involved 6-month follow-up with confocal microscopy to monitor tissue response and lens integration.

Main Results:

  • Initial interface edema resolved within one week post-implantation.

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  • No significant adverse events like flap melting or lens displacement were observed.
  • Excellent biocompatibility was noted at six months, with no signs of keratocytic activity or fibrosis.

    • Conclusions:

    • Intracorneal hydrogel lenses were well-tolerated by rabbit corneal stroma.
    • These lenses present a potentially safe alternative for hyperopia correction.
    • Clinical trials in humans are necessary to validate these findings.