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Histopathologic findings in explanted osteo-odontokeratoprosthesis
Josef Stoiber1, Désirée Csáky, Andreas Schedle
1Department of Ophthalmology and Optometry, St. Johanns-Spital, Landeskliniken Salzburg, Austria. j.stoiber@lks.at
Cornea
|April 26, 2002
Summary
Histologic analysis of explanted osteo-odontokeratoprosthesis (OOKP) laminae revealed tissue transformation and resorption. Inflammation and epithelial downgrowth were noted in some cases, highlighting the importance of the alveolar-dental ligament for OOKP integrity.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Histopathology
Background:
- Osteo-odontokeratoprosthesis (OOKP) is a complex surgical procedure for severe corneal blindness.
- Histologic evaluation of explanted OOKP laminae is crucial for understanding long-term device behavior and failure mechanisms.
Observation:
- Three OOKP laminae were explanted due to complications including leakage, spontaneous optic cylinder loss, and decentration.
- Histologic examination involved fixation, electrolytic decalcification, sectioning, and hematoxylin and eosin staining.
Findings:
- All explanted laminae exhibited transformation and resorption of bone and dentin.
- Patient 1 showed inflammatory reactions, epithelial downgrowth, and bone/dentin reduction.
- Patient 2's lamina was largely replaced by connective tissue with inflammatory signs; Patient 3 had no inflammation but lamina fragmentation.
Implications:
- Mechanisms like epithelial downgrowth and localized inflammation may contribute to OOKP lamina dissolution.
- Preservation of the alveolar-dental ligament appears critical for maintaining the structural integrity of the OOKP device.
- Further research is needed to elucidate definitive causes of OOKP lamina failure.