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[Isolated antenatal pyelic dilatation: postnatal follow-up and care for vesico-ureteral reflux]

M De Spirlet1, H B Lottmann, S Omnès

  • 1Service de Gynécologie Obstétrique, de Chirurgie Infantile et de Cytogénétique, Hôpital Robert Debré, 48, boulevard Sérurier, 75019 Paris et Faculté Paris VII Lariboisière-Saint Louis, Paris.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|April 26, 2002
PubMed

Insights

Isolated antenatal pyelic dilatation carries a low risk of aneuploidia (chromosome anomalies). However, associated postnatal vesico-ureteral reflux necessitates comprehensive prenatal ultrasound screening for affected infants.

Area of Science:

  • Pediatric Urology
  • Prenatal Diagnosis
  • Medical Genetics

Background:

  • Isolated antenatal pyelic dilatation is a common finding in prenatal ultrasounds.
  • The risk of associated aneuploidia (chromosome anomalies) requires careful assessment.
  • Understanding the urological implications is crucial for postnatal care.

Purpose of the Study:

  • To evaluate the risk of aneuploidia in fetuses with isolated antenatal pyelic dilatation.
  • To outline appropriate urological management strategies for affected children.

Main Methods:

  • Retrospective analysis of prenatal and postnatal follow-up data.
  • Inclusion of 350 cases with isolated antenatal pyelic dilatation.

Main Results:

  • An overall rate of 1.3% for chromosome anomalies was observed.
  • Trisomy 21 (Down syndrome) occurred in 0.3% of cases.
  • Vesico-ureteral reflux was present in 13% of infants, with similar rates in both sexes.

Conclusions:

  • The decision to perform karyotyping for isolated pyelic dilatation is complex, influenced by subtle findings like amniotic fluid volume.
  • The significant incidence of postnatal vesico-ureteral reflux underscores the importance of thorough prenatal ultrasound screening.
Abstract

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