Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

M L Coleman1, M F Olson

  • 1Cancer Research Campaign Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

Cell Death and Differentiation
|April 26, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ROCK2/ras<sup>Ha</sup> co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression.

Oncogene·2016
Same author

Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs.

Cell death and differentiation·2013
Same author

How apoptotic cells aid in the removal of their own cold dead bodies.

Cell death and differentiation·2012
Same author

Diverse styles of submarine venting on the ultraslow spreading Mid-Cayman Rise.

Proceedings of the National Academy of Sciences of the United States of America·2010
Same author

Activating ROCK1 somatic mutations in human cancer.

Oncogene·2010
Same author

Signalling cross talk of the HIF system: involvement of the FIH protein.

Current pharmaceutical design·2009
Same journal

A planar dimer of bovine ATP synthase.

Cell death and differentiation·2026
Same journal

GCN5 and TADA2B constitutively regulate XRCC1 function during DNA repair to maintain cell survival.

Cell death and differentiation·2026
Same journal

MEGF8 controls osteogenic differentiation through post-transcriptional regulation of BMP-SMAD signaling in craniosynostosis.

Cell death and differentiation·2026
Same journal

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis.

Cell death and differentiation·2026
Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026
See all related articles

Cellular removal through apoptosis is vital for development and repair. Rho GTPase signaling pathways regulate the actin cytoskeleton, crucial for clearing apoptotic cells efficiently.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Apoptosis, or programmed cell death, is essential for embryonic development, tissue homeostasis, wound repair, and inflammation resolution.
  • This process involves specific biochemical events leading to cell disassembly and phagocytosis.
  • The actin cytoskeleton undergoes dynamic rearrangements during apoptosis and phagocytosis.

Purpose of the Study:

  • To review the role of Rho GTPase signaling pathways in regulating cellular architecture.
  • To discuss how these pathways influence the actin cytoskeleton during apoptosis and phagocytosis.
  • To highlight the importance of these pathways for efficient apoptotic cell clearance.

Main Methods:

  • Literature review of recent research on Rho GTPase signaling.

Related Experiment Videos

  • Analysis of studies investigating actin cytoskeleton dynamics in apoptosis and phagocytosis.
  • Synthesis of findings on signal transduction pathways affecting cellular structure.

    • Main Results:

    • Rho GTPase signaling pathways are critical regulators of the actin cytoskeleton.
    • These pathways mediate the morphological changes necessary for apoptosis and phagocytosis.
    • Efficient clearance of apoptotic cells relies on proper regulation of actin dynamics.

    Conclusions:

    • Rho GTPase signaling is fundamental to the actin cytoskeleton's role in apoptotic cell removal.
    • Understanding these pathways can lead to insights into developmental and disease processes.
    • Targeting these pathways may offer therapeutic strategies for conditions involving impaired cell clearance.