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[Serum creatinphosphokinase (CPK) in endogenic psychoses]
Psychiatrie, Neurologie, Und Medizinische Psychologie
|March 1, 1975
Summary
Creatine phosphokinase (CPK) levels are typically normal in manic-depressive illness and most schizophrenia types. However, elevated CPK in catatonic schizophrenia may indicate an underlying physical illness, aiding diagnosis.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Context:
- Investigating biochemical markers in psychiatric disorders.
- Assessing the diagnostic utility of enzyme levels in psychosis.
- Examining Creatine Phosphokinase (CPK) in manic-depressive and schizophrenic patients.
Purpose:
- To determine Creatine Phosphokinase (CPK) levels in patients with manic-depressive and schizophrenic psychoses.
- To evaluate the correlation between CPK activity and specific psychotic subtypes.
- To assess the potential of CPK as a diagnostic and prognostic indicator in schizophrenia.
Summary:
- Creatine Phosphokinase (CPK) levels were analyzed in 141 patients with manic-depressive and schizophrenic psychoses.
- Normal CPK values were observed in manic-depressive disorders, chronic schizophrenia, and acute paranoid-hallucinatory schizophrenia.
- Significantly elevated CPK activities were predominantly found in catatonic schizophrenia, suggesting a potential somatic etiology.
Impact:
- Elevated CPK levels in catatonic schizophrenia may suggest an underlying physical illness, aiding in diagnosis.
- CPK determination can serve as a valuable tool for the diagnosis and monitoring of catatonic schizophrenia.
- This study highlights the potential of specific biochemical markers in differentiating subtypes of psychosis.