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[Macroglossia and occult amyloidosis].

Ana María Moroni1, Alicia Benavides, Yasmina Retamal

  • 1Unidad de Dermatología y Anatomía Patológica, Hospital Félix Bulnes C, Leoncio Fernández 2655, Quinta Normal, Santiago.

Revista Medica De Chile
|April 27, 2002
PubMed
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Amyloidosis, a rare protein deposition disease, can manifest with oral symptoms like macroglossia. This case highlights a fatal progression despite treatment, emphasizing the challenges in managing advanced amyloidosis.

Area of Science:

  • Medicine
  • Pathology

Background:

  • Amyloidosis is a rare condition involving abnormal extracellular protein deposits.
  • It can affect various organs, leading to significant health complications.

Observation:

  • A 78-year-old female presented with weight loss and tongue enlargement (macroglossia).
  • Oral examination revealed nodules on the tongue, indicative of amyloid infiltration.

Findings:

  • Pathological examination confirmed amyloid infiltration in oral nodules.
  • Bone marrow biopsy revealed plasma cell infiltration, suggesting an underlying plasma cell dyscrasia.

Implications:

  • This case underscores the diverse clinical presentations of amyloidosis.
  • Despite treatment with melphalan and prednisone, the patient experienced disease progression and mortality, highlighting the aggressive nature of some amyloidosis forms.

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