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[A case of eosinophilic pneumonia induced by Pelex granule]
Kumiko Hiramatsu1, Yuichiro Takeda, Yasuhiro Yamauchi
1Department of Respiratory Medicine, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
Abstract:
We report a case of eosinophilic pneumonia induced by Pelex granule. A 31-year-old male patient had been treated with Pelex granule and other drugs for common-cold symptoms such as cough and fever. Since these symptoms were persistent, he was admitted to our hospital for further examination. His laboratory findings showed eosinophilia and a mild elevation of serum IgE. Chest radiography revealed a reticular shadow and patchy shadows in both lung fields. Analysis of the bronchoalveolar lavage fluid (BALF) showed an increased percentage of eosinophils. The histological findings of the specimen obtained by transbronchial lung biopsy showed infiltration of eosniophils into the alveolar walls and spaces. After withdrawal of all drugs, the patient's clinical findings-symptoms, laboratory data, and chest radiographic findings-soon improved. A lymphocyte stimulation test (LST) for Pelex granule was positive. Taken together, the case was diagnosed as eosinophilic pneumonia induced by Pelex granule.
Insights
Pelex granule can cause eosinophilic pneumonia, a rare lung condition. This case highlights the importance of considering drug-induced lung injury in persistent respiratory symptoms.
Area of Science:
- Pulmonology
- Toxicology
- Internal Medicine
Background:
- Eosinophilic pneumonia is a group of lung diseases characterized by the infiltration of eosinophils into the lung parenchyma.
- Drug-induced lung diseases are an important cause of morbidity and mortality, and early diagnosis is crucial.
Observation:
- A 31-year-old male presented with persistent cough and fever, initially treated for common cold symptoms.
- Laboratory tests revealed eosinophilia and elevated serum IgE. Chest imaging showed bilateral reticular and patchy shadows.
- Bronchoalveolar lavage fluid (BALF) analysis demonstrated increased eosinophils, confirmed by transbronchial lung biopsy findings.
Findings:
- The patient's symptoms, laboratory results, and radiographic findings significantly improved after discontinuing all medications.
- A lymphocyte stimulation test (LST) for Pelex granule was positive, indicating a causal relationship.
- The case was diagnosed as eosinophilic pneumonia induced by Pelex granule.
Implications:
- This case underscores the potential for Pelex granule to induce eosinophilic pneumonia.
- Clinicians should consider drug-induced lung injury, including Pelex granule, in patients with unexplained pulmonary symptoms and eosinophilia.
- Further investigation into the mechanisms of Pelex granule-induced lung injury may be warranted.