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[Two fatal cases of methotrexate-induced interstitial pneumonitis]
Hidekazu Matsushima1, Noboru Takayanagi, Ichiro Kawata
1Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
Abstract:
We report two cases of methotrexate-induced pneumonitis. Both patients died despite steroid pulse therapy. Postmortem lung tissue revealed diffuse alveolar damage, and focal lung fibrosis. Physicians should be aware of the possibility of MTX-induced interstitial pneumonitis in diagnosing RA patients with MTX when diffuse pulmonary infiltration is present.