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Synthesis and structure-activity relationship study of lamellarin derivatives
Fumito Ishibashi1, Shinji Tanabe, Tatsuya Oda
1Division of Marine Life Science and Biochemistry, Faculty of Fisheries, and Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 1-14 Bunkyo-Machi, Nagasaki 852-8521, Japan. fumito@net.nagasaki-u.ac.jp
Journal of Natural Products
|April 27, 2002
Abstract:
Ten derivatives (3-12) of marine alkaloid lamellarin D (1) were synthesized and evaluated for cytotoxicity against a HeLa cell line in an effort to examine their structure-activity relationships. It appeared that the hydroxyl groups at positions C-8 and C-20 of 1 were important structural requirements for cytotoxic activity, while the hydroxyl group at C-14 and the two methoxy groups at C-13 and C-21 were not necessary for the activity.