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Total synthesis and bioactivity of some naturally occurring pterulones
Bas W T Gruijters1, Albertus van Veldhuizen, Carel A G M Weijers
1Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands.
Journal of Natural Products
|April 27, 2002
Abstract:
The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy)benzoate (6) by employing ring-closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorulaglutinis and Saccharomyces cerevisiae.