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Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation
Alfredo Ribeiro-Silva1, A Novello-Vilar, A M Cunha-Mercante
1Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP/USP), Avenida Bandeirantes, s/n-Campus Universitário Monte Alegre, CEP 14048-900, Ribeirão Preto-SP, São Paulo, Brazil. ardsilva@rpa.fmrp.usp.br
Abstract:
Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.