Related Experiment Video
Updated: Sep 10, 2026

Isolation of Functional Cardiac Immune Cells
Published on: December 5, 2011
The role of tumor necrosis factor in cardiac disease
1Department of Internal Medicine, Temple University Hospital, Philadelphia, Pennsylvania 19004, USA.
Abstract:
Tumor necrosis factor (TNF) is a proinflammatory cytokine that can produce widespread deleterious effects when expressed in large amounts. It is produced in the heart by both cardiac myocytes and resident macrophages under conditions of cardiac stress, and is thought to be responsible for many of the untoward manifestations of cardiac disease. This article discusses the role of TNF in heart disease and some potential therapeutic modalities that can influence the cytokine activity. The results of controlled studies would suggest that TNF inhibition does not influence the clinical course of patients with heart failure.
Related Concept Videos
The Tumor Microenvironment
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Pathophysiology of Heart Failure
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Myocarditis I: Introduction
Cellular Injury IV: Necrosis

