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GAP-43 expression and pathological changes of temporal infarction in rats and effects of batroxobin
Weiping Wu1, Xingzhi Guan, Xiaoshu Zhang
1Neurotransmitter Research Laboratory, Department of Neurology, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing 100853.
Unlabelled:
To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin.
Methods:
Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology.
Results:
In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group.
Conclusion:
The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.