[Effects on micro-vessel density after pre-operative intra-arterial infusion chemotherapy in colorectal cancer]
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Updated: Oct 1, 2026
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Qing Lin1, Zhixia Li, Lijun Zhang
1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Objective:
To evaluate the effects of pre-operative intra-arterial infusion chemotherapy on colorectal cancer.
Methods:
Twenty-eight patients with colorectal cancer, treated by surgery from February to October 2000, were divided into two groups randomly. There were 12 patients in group A (pre-operative intra-arterial infusion chemotherapy) and 16 in group B (control). Arterial contrast technique was used in group A, then mitromycin 10 mg, 5-Fu 1,000 mg, epirubicin 60 mg were given through Weidner's way.
Results:
Micro-vessel density in the center, surface of the tumor and adjacent tissue around the tumor were 40.46 +/- 7.06, 52.27 +/- 18.40, 49.92 +/- 8.15 in group A, and 46.09 +/- 12.21, 73.44 +/- 22.06, 51.94 +/- 12.64 in group B. Micro-vessel density on the surface in group A was significantly lower than that of group B (P < 0.05), with no significance between the center and the adjacent tissue.
Conclusion:
Pre-operative intra-arterial infusion chemotherapy is able to reduce micro-vessel density on the surface of colorectal tumor.
