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Nutrient absorption and intestinal adaptation with ageing.

Trudy Woudstra1, Alan B R Thomson

  • 1Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada.

Best Practice & Research. Clinical Gastroenterology
|April 30, 2002
PubMed
Summary
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Malabsorption issues in the elderly can worsen malnutrition due to impaired intestinal adaptation. Nutritional interventions may improve nutrient absorption and benefit age-related conditions like dyslipidemia and diabetes.

Area of Science:

  • Gerontology
  • Gastroenterology
  • Nutritional Science

Background:

  • Aging is associated with impaired intestinal absorption of macronutrients, micronutrients, and amino acids.
  • Reduced intestinal adaptability in the elderly can exacerbate malnutrition.
  • Age-related conditions like dyslipidemia and diabetes are prevalent and may be influenced by nutrient absorption.

Purpose of the Study:

  • To explore the impact of aging on intestinal nutrient absorption.
  • To investigate the potential of dietary manipulation to enhance intestinal absorption in older adults.
  • To identify nutritional strategies for managing age-associated metabolic conditions.

Main Methods:

  • Review of existing literature on aging, intestinal absorption, and malnutrition.

Related Experiment Videos

  • Analysis of age-related changes in nutrient transport mechanisms.
  • Exploration of the link between nutrient absorption and conditions like dyslipidemia and diabetes.

    • Main Results:

    • Malabsorption of carbohydrates, lipids, amino acids, minerals, and vitamins is a documented issue in the elderly.
    • Intestinal adaptive capacity may decline with age, contributing to malnutrition.
    • Nutritional interventions show promise for improving nutrient absorption and managing age-related diseases.

    Conclusions:

    • Dietary manipulation is a potential strategy to enhance intestinal absorption in the aging population.
    • Targeted nutritional interventions could benefit individuals with age-associated dyslipidemia and diabetes.
    • Future research into proteins regulating sterol and fatty acid absorption may yield new therapeutic options.