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Lansoprazole-induced thrombocytopenia
Jonathan A Zlabek1, Christopher G Anderson
1Department of Internal Medicine, Gundersen Lutheran Medical Center, 1836 South Avenue, La Crosse, WI 54601-5494, USA. jzlabek@gundluth.org
The Annals of Pharmacotherapy
|April 30, 2002
Summary
This case report details a patient who developed severe thrombocytopenia (low platelet count) after taking lansoprazole. Discontinuing the medication led to a normal platelet count, suggesting a drug-induced adverse reaction.
Area of Science:
- Pharmacology
- Hematology
- Gastroenterology
Background:
- Proton pump inhibitors (PPIs) like lansoprazole are commonly prescribed for acid-related gastrointestinal disorders.
- Adverse drug reactions, though rare, necessitate careful monitoring in clinical practice.
Observation:
- An 85-year-old male presented with upper gastrointestinal hemorrhage and was initiated on lansoprazole.
- Following lansoprazole administration, the patient experienced a rapid and significant decrease in platelet count.
- Platelet levels normalized after the discontinuation of lansoprazole.
Findings:
- The case presents the first reported instance of isolated thrombocytopenia potentially induced by lansoprazole.
- The temporal relationship between lansoprazole use, thrombocytopenia onset, and resolution strongly suggests an idiosyncratic drug reaction.
- Exclusion of other potential causes supports lansoprazole as the likely etiology.
Implications:
- Clinicians should consider lansoprazole as a potential cause of thrombocytopenia in patients presenting with low platelet counts.
- Prompt discontinuation of lansoprazole is recommended if thrombocytopenia is suspected to be drug-induced.
- This case highlights the importance of pharmacovigilance for PPIs and their potential hematologic side effects.