Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidatively modified proteins in aging and disease.

M Flint Beal1

  • 1Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10021, USA. fbeal@mail.med.cornell.edu

Free Radical Biology & Medicine
|April 30, 2002
PubMed
Summary

Oxidative damage, measured by protein carbonyls and 3-nitrotyrosine, is linked to normal aging and neurodegenerative diseases like Alzheimer's and Parkinson's. This supports exploring antioxidants for these conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2022
Same author

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.

Nature communications·2022
Same author

Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model.

Neuropathology and applied neurobiology·2021
Same author

Isotope-reinforced polyunsaturated fatty acids improve Parkinson's disease-like phenotype in rats overexpressing α-synuclein.

Acta neuropathologica communications·2020
Same author

Changes of Coenzyme A and Acetyl-Coenzyme A Concentrations in Rats after a Single-Dose Intraperitoneal Injection of Hepatotoxic Thioacetamide Are Not Consistent with Rapid Recovery.

International journal of molecular sciences·2020
Same author

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing.

Nature reviews. Drug discovery·2020

Area of Science:

  • Biochemistry
  • Neuroscience
  • Gerontology

Background:

  • Oxidative damage is implicated in aging and neurodegenerative diseases.
  • Protein oxidation is a significant aspect of this damage.
  • Specific markers like protein carbonyls and 3-nitrotyrosine are key indicators.

Purpose of the Study:

  • To review the role of oxidative damage markers in aging and neurodegeneration.
  • To highlight the significance of protein carbonyls and 3-nitrotyrosine.
  • To establish a rationale for antioxidant therapies.

Main Methods:

  • Literature review of studies on oxidative stress markers.
  • Analysis of protein carbonyl and 3-nitrotyrosine concentrations.
  • Comparison of findings in normal aging versus neurodegenerative conditions.

Related Experiment Videos

Main Results:

  • Increased protein carbonyls and 3-nitrotyrosine are observed in normal aging.
  • Elevated levels of these markers are found in Alzheimer's disease, Parkinson's disease, and ALS.
  • 3-Nitrotyrosine is a specific marker for peroxynitrite-mediated damage.

Conclusions:

  • Oxidative protein damage is a common feature of aging and neurodegenerative diseases.
  • Markers like protein carbonyls and 3-nitrotyrosine are consistently elevated.
  • These findings provide a scientific basis for investigating antioxidant treatments.