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Neonatal alloimmune thrombocytopenia with significant HLA antibodies
J D Grainger1, G Morrell, J Yates
1Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK. igrainger@bigfoot.com
Archives of Disease in Childhood. Fetal and Neonatal Edition
|April 30, 2002
Abstract:
A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.