Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoid addiction: behavioral models and neural correlates.

Rafael Maldonado1, Fernando Rodríguez de Fonseca

  • 1Laboratori de Neurofarmacologia, Facultat de Cienciés de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain. rafael.maldonado@cexs.upf.es

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 30, 2002
PubMed
Summary

Recent animal models explore cannabinoid addiction and its neural basis. This review focuses on the CB1 receptor

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent stress and alcohol are associated with CX<sub>3</sub>CR1-linked endocrine-cardiac signatures and anxiety-like behavior in mice.

Frontiers in pharmacology·2026
Same author

Alcohol-fluoxetine co-treatment drives gut dysbiosis and intestinal barrier disruption with consequences for neuroimmune signaling in male rats.

Neuropharmacology·2026
Same author

D-chiro-inositol modulates brain insulin-related signaling and reduces amyloid burden, neuroinflammation and cognitive decline in preclinical models of Alzheimer's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Neuropsychological effects of cannabis use by continent and age: a systematic review.

Frontiers in psychology·2026
Same author

Maternal deprivation and adolescent alcohol exposure induce sex-dependent alterations in stress-related behavior and lipid signaling in rats.

Biology of sex differences·2026
Same author

Plasma Concentrations of Endotoxin Lipopolysaccharide and High-Mobility Group Box 1 Protein Are Consistent Sex-Specific Biomarkers of Alcohol Abstinence Associated with Alcohol Use Disorder.

Toxics·2026

Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Cannabis sativa has a long history of recreational use.
  • Understanding cannabinoid addiction requires robust animal models.
  • Neural mechanisms underlying cannabinoid abuse are not fully elucidated.

Purpose of the Study:

  • To review recent animal models of cannabinoid addiction.
  • To explore the role of the CB1 cannabinoid receptor in addiction.
  • To examine interactions between cannabinoid, opioid, and dopamine systems in reward circuits.

Main Methods:

  • Review of existing literature on cannabinoid addiction models.
  • Analysis of studies investigating the CB1 receptor.
  • Examination of neurochemical pathways involved in reward.

Related Experiment Videos

Main Results:

  • Development of novel animal models for studying cannabinoid addiction.
  • Identification of the CB1 receptor as a key player in cannabinoid abuse.
  • Evidence for interactions between cannabinoid and other neurotransmitter systems (opioid, dopamine).

Conclusions:

  • Animal models are crucial for understanding cannabinoid addiction.
  • The CB1 receptor is a significant target for addiction research.
  • Reward circuit interactions are central to cannabinoid's addictive potential.