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Related Experiment Videos

Cyclin-dependent kinase 5 is required for associative learning.

André Fischer1, Farahnaz Sananbenesi, Christina Schrick

  • 1Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany. fischer@mail.em.mpg.de

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 30, 2002
PubMed
Summary

Stressful experiences enhance learning by altering gene expression. The study found that increased Cyclin-dependent kinase 5 (Cdk5) activity in the brain is crucial for this stress-induced associative learning.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Transient stress can lead to lasting changes in learning and memory.
  • Gene expression alterations are a potential mechanism underlying stress-induced learning facilitation.

Purpose of the Study:

  • To investigate the role of gene expression changes in stress-induced learning.
  • To identify specific genes and pathways involved in stress and memory.

Main Methods:

  • Subtractive hybridization was used to identify differentially expressed genes.
  • Cdk5 (Cyclin-dependent kinase 5) gene expression and kinase activity were analyzed.
  • The effect of a Cdk5 inhibitor (butyrolactone I) on fear conditioning was assessed.

Main Results:

Related Experiment Videos

  • The Cdk5 gene was found to be differentially expressed in response to stress.
  • Cdk5 protein and kinase activity were selectively increased in septohippocampal cholinergic neurons.
  • Inhibiting Cdk5 activity blocked the acquisition and stress-induced facilitation of conditioned fear.

Conclusions:

  • A transient increase in Cdk5 activity within the septohippocampal system is essential for associative learning.
  • This study identifies a novel role for Cdk5 in mediating the effects of stress on learning.