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Updated: Oct 1, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders
Shih-Jen Tsai1, Wen-Chen Ouyang, Chen-Jee Hong
1Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC.
Abstract:
In contrast with two previous western reports, a recent study on a Chinese population found an association for allele 12 of the variable number tandem repeat (VNTR) in the second intron of the serotonin transporter (5-HTT) gene and schizophrenic disorders. We have replicated this finding for a Chinese population in Taiwan (114 schizophrenic patients and 127 controls), demonstrating a modest but significant statistical association for the 5-HTT-VNTR allele 12 and schizophrenic patients (one-sided p = 0.043). This positive finding further supports the proposition that the 5-HTT-VNTR allele 12 is a risk factor for schizophrenic disorders in Chinese populations, although the effect is weak.
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