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[Pharmacokinetic of prednisolone in patients with rheumatoid arthritis]
Terapevticheskii Arkhiv
|May 1, 2002
Abstract
Aim:
To study pharmacokinetics of prednisolone in patients with rheumatoid arthritis (RA).
Material And Methods:
The examination of 10 RA patients included blood tests for glucocorticoids 1, 2, 4 and 6 hours after the drug intake. Serum steroids were measured using high performance liquid chromatography. Pharmacokinetic parameters were estimated in one-chamber model with absorption.
Results:
In spite of the same dose of prednisolone, its serum concentration as well as pharmacokinetic parameters were individual in each patient.
Conclusion:
Pharmacokinetic indices of prednisolone in RA patients provide more reliable information for design of treatment scheme for each patient individually.