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[Current problems of viral and alcohol diseases of the liver]
Insights
Hepatitis B
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Context:
- Analysis of 517 acute viral hepatitis (AVH) and 1203 hepatic cirrhosis (HC) cases.
- Examined trends over 20-28 years, focusing on HBV infection's declining role.
- Assessed lethality rates for various cirrhosis types and the impact of alcohol consumption policies.
Purpose:
- To analyze trends in acute viral hepatitis and hepatic cirrhosis etiology and outcomes.
- To evaluate the changing roles of viral (HBV, HCV) and alcoholic factors in liver disease.
- To determine prognosis and lethality associated with different forms of hepatic cirrhosis.
Summary:
- HBV infection's contribution to AVH and HC has decreased.
- Alcoholic hepatic cirrhosis lethality declined 2.5-fold when alcohol sales were restricted.
- Alcoholic and polyviral hepatic cirrhoses now present the worst prognosis, with over 50% lethality.
Impact:
- Highlights the significant impact of public health interventions on alcohol-related liver disease.
- Indicates a shift in the primary drivers of severe liver disease.
- Underscores the need for targeted strategies against combined alcoholic-viral and polyviral etiologies.
Abstract:
517 cases of acute viral hepatitis (AVH) and 1203 cases of hepatic cirrhosis (HC) have been analysed. In recent 20-28 year the trend to a decline in the role of HBV infection in the origin of both AVH and HC. The least lethality was reported for viral C-cirrhoses. When the sale of heavy drinks was limited by the law, lethality of alcoholic hepatic cirrhosis came down 2.5-fold. Among hepatic cirrhoses, the percentage of alcoholic forms has increased from 35.6% in 1972-1984 to 41.5% in 1996-2000. The worst prognosis is now stated for alcoholic-viral and polyviral hepatic cirrhoses. The data for 4.5 years evidence for at least 50% lethality in this group.
