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[The Pneumococcal Observatory for the Central Region, 1 April 1999 to 31 March 2000].

B Cattier1, S Lempérière, I Gallois

  • 1CHU Bretonneau, 37044 Tours, France.

Pathologie-Biologie
|May 1, 2002
PubMed
Summary

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Over half of pneumococcus strains studied showed reduced susceptibility to penicillin (PRSP). Many PRSP strains, particularly in children and ear infections, were resistant or intermediate to benzylpenicillin.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Streptococcus pneumoniae (pneumococcus) is a leading cause of bacterial infections.
  • Penicillin resistance in pneumococcus is a growing global health concern.
  • Surveillance of antimicrobial susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To assess the prevalence of penicillin-resistant Streptococcus pneumoniae (PRSP) in the Centre region.
  • To determine the antimicrobial susceptibility profiles of PRSP strains.
  • To identify common serotypes among PRSP isolates.

Main Methods:

  • Collection of 796 pneumococcus strains from 15 laboratories over one year.
  • Susceptibility testing using E-test and disc diffusion for various antibiotics.

Related Experiment Videos

  • Minimum Inhibitory Concentrations (MICs) performed by agar dilution for PRSP strains.
  • Serotyping of PRSP isolates.

    • Main Results:

    • 56.7% of strains were categorized as penicillin-resistant Streptococcus pneumoniae (PRSP).
    • PRSP prevalence was higher in children (70.1%) and ear pus samples (85.7%).
    • Of 400 PRSP strains, 26.5% were resistant and 73.5% intermediate to benzylpenicillin; 9% were resistant to amoxicillin and 2.5% to cefotaxime.

    Conclusions:

    • A significant proportion of pneumococcus strains in the Centre region exhibit reduced susceptibility to penicillin.
    • PRSP is a considerable issue, especially in pediatric populations and specific infection types.
    • Continued monitoring of antimicrobial resistance patterns and serotype distribution is essential.