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Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets
Dorthea Johnson-Alvares1, Germaine Cornélissen, Ana Portela
1Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.
Background:
Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.
Materials And Methods:
CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.
Results:
CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.
Conclusions:
Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.
