Jove
Visualize
Contact Us

Related Experiment Videos

[Melioidosis].

I Leeuwenburgh1, J T N Driessen, P H J van Keulen

  • 1Afd. Interne Geneeskunde, Amphia Ziekenhuis (locatie Langendijk), Langendijk 75, 4819 EV Breda. i.leeuwenburgh@xs4all.nl

Nederlands Tijdschrift Voor Geneeskunde
|May 1, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-sample fecal immunochemical testing as a tool to avert colonoscopy in symptomatic patients: a prospective multicenter cohort study.

Endoscopy·2025
Same author

Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's-associated adenocarcinoma?

Biochimica et biophysica acta. Reviews on cancer·2019
Same author

Fasciola hepatica as a cause of jaundice after chewing khat: a case report.

The Netherlands journal of medicine·2013
Same author

Evaluation of brilliance MRSA 2 agar for detection of methicillin-resistant Staphylococcus aureus in clinical samples.

Journal of clinical microbiology·2013
Same author

Secular trends in nosocomial bloodstream infections: antibiotic-resistant bacteria increase the total burden of infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2012
Same author

Barrett's esophagus and esophageal adenocarcinoma are common after treatment for achalasia.

Digestive diseases and sciences·2012
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Melioidosis, a serious bacterial infection caused by Burkholderia pseudomallei, can be effectively treated with ceftazidime and oral antibiotics. Early diagnosis and prolonged treatment are crucial to prevent relapse of this endemic disease.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Tropical Medicine

Background:

  • Melioidosis is caused by Burkholderia pseudomallei, an endemic bacterium in Southeast Asia and Northern Australia.
  • The disease presents a wide clinical spectrum, from sepsis to subclinical forms, often affecting the lungs.
  • High mortality rates (40%) and relapse rates (4-20%) are associated with the septicaemic form.

Observation:

  • A 34-year-old woman presented with symptoms including fever, cough, and leg swelling after visiting Burma.
  • Burkholderia pseudomallei was identified as the causative agent.
  • Initial treatment with intravenous amoxycillin-clavulanic acid was followed by ceftazidime.

Findings:

  • The patient recovered after treatment with ceftazidime.

Related Experiment Videos

  • A six-month course of amoxycillin-clavulanic acid was administered to prevent relapse.
  • The optimal treatment involves intravenous ceftazidime followed by a 3-month oral eradication phase.

    • Implications:

    • Prompt and appropriate antibiotic therapy is vital for managing melioidosis.
    • Prolonged treatment regimens are necessary to reduce the high risk of relapse.
    • Understanding the pathogen's ability to persist intracellularly highlights the need for extended treatment to prevent chronic disease and reactivation.