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Updated: Aug 29, 2026

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
Published on: July 10, 2017
Socioeconomic status, depressive symptoms, and adolescent substance use
1Division of Adolescent Medicine, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA. goode0@chmcc.org
Objective:
To determine the relationships among socioeconomic status (SES), depression, and substance use among teenagers. We hypothesized that, among teenagers, substance use was associated with SES in a graded fashion and that depression is a mechanism through which SES affects substance use behaviors.
Design:
Linear regression analyses of cross-sectional data from Wave I of the National Longitudinal Study of Adolescent Health (1995).
Participants:
Fifteen thousand one hundred twelve adolescents whose parents answered questions assessing household income and parental education.
Main Outcome Measures:
Use of cigarettes, alcohol, marijuana, and cocaine.
Results:
For all 4 substances, frequency of use varied by SES. In the total population, inverse SES gradients were present for cigarette use (education, mean change= -0.052; 95% confidence interval [CI], -0.081 to -0.023; income, mean change= -0.038; 95% CI, -0.069 to -0.007) and alcohol use (income, mean change= 0.044; 95% CI, 0.016-0.071). The relationship between marijuana use and education was also significant but inverse-U-shaped, not linear. This relationship was only present among nonwhite teenagers. Race/ethnicity also moderated the relationships between SES and cigarette use and SES and cocaine use. For cigarette use, stratification by race/ethnicity revealed an inverse graded relationship among white non-Hispanic teenagers and a direct, graded relationship among nonwhite teenagers (ie, mean change for education among white non-Hispanic teenagers, -0.012; 95% CI, -0.016 to -0.075; mean change for education among nonwhite teenagers, 0.040; 95% CI, 0.014-0.072). For cocaine use, a weak, inverse linear relationship existed only between education and cocaine use among white non-Hispanic teenagers (mean change for education, -0.013; 95% CI, -0.026 to -0.0004). The relationship between the SES indicator and substance use weakened when depressive symptoms were entered into the model for the SES-cigarette use relationship (23% decrease in mean change associated with a 1-unit change in both education and income) and for the association between education and cocaine use among white non-Hispanic teenagers (31% decrease).
Conclusions:
Socioeconomic status is associated with substance use among teenagers but the nature of the relationship is not consistent across SES indicators or across race/ethnicity groups. Depressive symptoms are a mechanism through which SES affects cigarette and cocaine use behaviors among teenagers. However, these data indicate that interventions targeted toward decreasing depressive symptoms will not have a strong impact on the effects of SES on teenage substance use.
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