Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental studies on curing elapid bite with trypsin.

H Yü-liang, T Ju-chin, H Yi-ti

    Scientia Sinica
    |May 1, 1975
    PubMed
    Summary

    Local injection of trypsin offers a novel, broad-spectrum therapy for venomous snakebites. Prompt administration effectively neutralizes elapid and cobra venom, even hours after the bite, with minimal side effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same journal

    Studies on developmental biology of embryogenesis in higher plants--effect of actinomycin D and cycloheximide on the formation of peroxidase during rice and embryogenesis and germination.

    Scientia Sinica·1981
    Same journal

    The "bolus flow" solution of the plasma between the red blood cells flowing through a capillary.

    Scientia Sinica·1981
    Same journal

    [3H-Methyl]-methionine as possible methyl donor for formation of 5'-terminus of in vitro synthesized mRNA of cytoplasmic polyhedrosis virus of silkworm Bombyx mori.

    Scientia Sinica·1981
    Same journal

    The nature of radiation damage of haemopoietic stem cells under continuous irradiation at low dose rate.

    Scientia Sinica·1981
    Same journal

    The gene frequency of serum albumin variants in Chinese and the electrophoretic characterization of several serum albumin variants.

    Scientia Sinica·1981
    Same journal

    The primary structure of snake (Zaocys dhumnades dhumnades, Cantor) insulin.

    Scientia Sinica·1981

    Area of Science:

    • Biochemistry
    • Toxicology
    • Emergency Medicine

    Background:

    • Venomous snakebites pose a significant global health threat.
    • Current treatments like antivenins can be specific and have limitations.
    • There is a need for accessible, broad-spectrum treatments for snake envenomation.

    Purpose of the Study:

    • To evaluate the efficacy of local trypsin injection as a novel therapy for venomous snakebites.
    • To determine the optimal timing and effectiveness of trypsin administration post-envenomation.

    Main Methods:

    • Experiments were conducted on mice and dogs injected with lethal doses of elapid and cobra venom.
    • Local trypsin injections were administered at varying time intervals post-venom injection.
    • Survival rates and systemic poisoning symptoms were monitored.

    Main Results:

    • All animals survived lethal elapid venom injections with prompt local trypsin.
    • 90-100% of mice survived cobra venom envenomation when treated within 50 minutes.
    • Local trypsin demonstrated broad-spectrum activity against different venoms with no severe side effects.

    Conclusions:

    • Local trypsin injection is a highly effective and broad-spectrum first-aid treatment for venomous snakebites.
    • Trypsin's ease of production, storage, and potential for auto-injector delivery makes it a promising therapeutic option.
    • This therapy remains effective even when administered significantly after the snakebite, targeting venom in local tissues.

    Related Experiment Videos