Related Experiment Video
Updated: Jul 24, 2026
07:28
An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
Published on: April 15, 2015
Gene and antisense delivery in alcoholism research
Y Israel1, F T Crews, R G Thurman
1Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. yedy.israel@mail.tju.edu
Alcoholism, Clinical and Experimental Research
|May 1, 2002
Summary
This symposium explored advanced gene delivery and therapy techniques for alcohol-related conditions. Researchers discussed gene therapy for alcoholic liver injury and novel antisense oligonucleotide applications.
Area of Science:
- Neuroscience
- Hepatology
- Molecular Biology
Background:
- The symposium focused on novel therapeutic strategies for alcohol-related disorders.
- Alcoholism poses significant challenges requiring innovative treatment approaches.
Framework:
- The symposium proceedings covered gene delivery to the brain.
- It included discussions on gene therapy for alcoholic liver injury.
- Antisense oligonucleotides and gene delivery were also presented.
Implementation:
- Presentations detailed methods for introducing genetic material into the brain.
- Strategies for utilizing gene therapy to mitigate liver damage from alcohol were examined.
- The application of antisense technology for therapeutic purposes was explored.
Implications:
- These advanced gene-based approaches hold potential for treating alcoholism and its associated organ damage.
- Further research into gene delivery and therapy could revolutionize alcohol use disorder treatment.
- The symposium highlighted the growing role of molecular biology in addressing alcohol-related health issues.
More Related Videos
Related Concept Videos
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
00:59Gene Therapy
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
02:30siRNA - Small Interfering RNAs
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
02:15Experimental RNAi
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...