Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulating airway defenses against microbes.

Herbert Y Reynolds1

  • 1J. Lloyd Huck Professor of Medicine, Chair, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033-0850, USA. hreynolds@psu.edu

Current Opinion in Pulmonary Medicine
|May 1, 2002
PubMed
Summary

Preventing respiratory infections is crucial due to an aging population and new pathogens. This review explores host defenses and microbe interactions to improve vaccine strategies against common respiratory pathogens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

As the medical education curriculum is changing, it is still good to train students and physicians in many different patient locations.

Lung·2014
Same author

Back to the beginning for the Eighth Evacuation Hospital in Morocco during World War II 70 years ago.

Transactions of the American Clinical and Climatological Association·2014
Same author

Various approaches to clinically related research can yield helpful insight. A personal perspective.

American journal of respiratory and critical care medicine·2013
Same author

Re: Mentoring and coaching in medicine.

The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2012
Same author

Bronchoalveolar lavage and other methods to define the human respiratory tract milieu in health and disease.

Lung·2011
Same author

Medical ear in the early morning tennis group--when to advise and what to say.

The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha·2010

Area of Science:

  • Respiratory medicine
  • Immunology
  • Microbiology

Background:

  • Respiratory infections pose a significant healthcare challenge, exacerbated by an aging population, increased susceptibility, and emerging antibiotic-resistant bacteria.
  • Existing vaccines for common microbes are underutilized, despite their protective potential for both children and adults.
  • Evolving definitions of high-risk populations necessitate broader immunization strategies.

Purpose of the Study:

  • To review host defense mechanisms in the human respiratory tract at three distinct levels: naso-oropharynx, conducting airways, and alveolar space.
  • To examine microbe-host interactions at each airway level, considering representative pathogenic microbes.
  • To identify potential new approaches for preventing respiratory infections based on updated knowledge of host defenses and microbial pathogenesis.

Related Experiment Videos

Main Methods:

  • Literature review and synthesis of current research on respiratory tract host defense mechanisms.
  • Analysis of microbe-host interactions for key respiratory pathogens, including influenza, Streptococcus pneumoniae, and Bacillus anthracis.
  • Identification of potential targets for novel vaccine development and preventative strategies.

Main Results:

  • Detailed examination of host defenses in the upper airways, conducting airways, and alveolar spaces.
  • Examples of pathogens like influenza virus, Streptococcus pneumoniae, and Bacillus anthracis are mapped to their respective infection sites.
  • Understanding of microbe-host interactions provides insights into infection pathways.

Conclusions:

  • Enhanced understanding of host defense mechanisms across respiratory tract segments is vital for combating infections.
  • Exploring microbe-host interactions can guide the development of innovative vaccines and preventative measures.
  • Addressing underutilization of current vaccines and developing new ones are key to managing respiratory health challenges.