Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gout and hyperuricemia.

Robert L Wortmann1

  • 1Department of Internal Medicine, The University of Oklahoma College of Medicine, Tulsa 74135, USA. Robert-wortmann@ouhsc.edu

Current Opinion in Rheumatology
|May 1, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical features related to statin-associated muscle symptoms.

Muscle & nerve·2018
Same author

The causes of drug-induced muscle toxicity.

Current opinion in rheumatology·2014
Same author

Noninflammatory myopathies.

Rheumatic diseases clinics of North America·2013
Same author

Latest evidence on gout management: what the clinician needs to know.

Therapeutic advances in chronic disease·2013
Same author

Hyperuricemia and gout: new concepts in diagnosis and management.

Postgraduate medicine·2013
Same author

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.

Arthritis and rheumatism·2012
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Gout and hyperuricemia are global health issues, influenced by genetics and lifestyle factors like diet and obesity. Effective urate removal is key to managing gout, with allopurinol and uricosuric agents offering treatment options.

Area of Science:

  • Rheumatology
  • Metabolic Diseases
  • Public Health

Background:

  • Gout remains a significant global health concern despite available treatments.
  • Prevalence is increasing, particularly in African and Oriental countries, linked to genetic factors, alcohol, obesity, and hypertension.
  • Hyperuricemia is associated with cardiovascular disease, potentially mediated by insulin resistance, explaining comorbidities like hyperlipidemia and glucose intolerance in gout patients.

Purpose of the Study:

  • To review the current understanding of gout and hyperuricemia prevalence and contributing factors.
  • To discuss the relationship between hyperuricemia, metabolic syndrome components, and cardiovascular disease.
  • To highlight treatment strategies for gout, focusing on urate-lowering therapies and managing associated conditions.

Main Methods:

Related Experiment Videos

  • Literature review of studies on gout, hyperuricemia, and associated metabolic and cardiovascular conditions.
  • Analysis of factors influencing gout prevalence, including genetics, lifestyle, and comorbidities.
  • Evaluation of current therapeutic approaches, including urate-lowering agents and lifestyle modifications.

Main Results:

  • Genetic factors play a role, but lifestyle factors like alcohol consumption, obesity, and hypertension significantly contribute to gout and hyperuricemia prevalence.
  • Insulin resistance links hyperuricemia to cardiovascular disease, explaining the frequent co-occurrence of hyperlipidemia and glucose intolerance in gout patients.
  • Dietary manipulation, alongside management of hypertension and obesity, is crucial for gout patients. Allopurinol is a primary urate-lowering agent, but allergic reactions necessitate alternatives like uricosuric agents.

Conclusions:

  • Comprehensive management of gout requires addressing lifestyle factors and comorbidities, not just acute attacks.
  • Effective urate removal is essential for gout elimination, with ongoing development of treatment strategies for patients intolerant to allopurinol.
  • Further research into alternative urate-lowering therapies and personalized management plans for gout patients is warranted.