Left ventricular diastolic function is related to glucose in a middle-aged population

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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

M Holzmann1, A Olsson, J Johansson

  • 1Department of Cardiology, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden. martin.holzmann@ks.se

Journal of Internal Medicine
|May 2, 2002
PubMed

Insights

Elevated glucose levels, even below the diabetes threshold, negatively impact left ventricular diastolic function. This study shows a link between fasting plasma glucose, postload glucose, and glycated hemoglobin with cardiac function in adults.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Diagnostic Imaging

Background:

  • Left ventricular (LV) diastolic dysfunction is a precursor to heart failure.
  • Glucose metabolism disturbances are linked to cardiovascular disease.
  • Early detection of cardiac changes related to metabolic health is crucial.

Purpose of the Study:

  • To investigate the relationship between left ventricular (LV) diastolic function and glucose metabolism markers.
  • To assess if impaired diastolic function occurs in individuals without diagnosed diabetes.

Main Methods:

  • Cross-sectional population-based study involving 35 adults aged 56-58 without diabetes or heart disease.
  • Assessed LV diastolic function using pulsed Doppler tissue imaging, measuring Em, Am, and Em/Am ratios.
  • Correlated LV diastolic function parameters with fasting plasma glucose, postload glucose, and glycated hemoglobin (HbA1c).

Main Results:

  • Significant correlations were found between LV diastolic function parameters (Em, Am, Em/Am) and fasting plasma glucose.
  • LV diastolic function also correlated with glycated hemoglobin and postload glucose levels.
  • These associations were observed in individuals with glucose levels below the diabetes diagnostic threshold.

Conclusions:

  • Left ventricular diastolic function is associated with glucose metabolism markers, including fasting plasma glucose, postload glucose, and glycated hemoglobin, even in individuals without diabetes.
  • Glucose concentrations in the upper normal range can negatively affect cardiac function.
  • These findings highlight the importance of monitoring glucose metabolism for early detection of cardiac changes.
Abstract

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