Related Experiment Videos
Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope
Eric C Schirmer1, Larry Gerace
1Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. lgerace@scripps.edu
Genome Biology
|May 2, 2002
Abstract:
Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.