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Genome scans and microarrays: converging on genes for schizophrenia?
Nigel M Williams1, Michael C O'Donovan, Michael J Owen
1Department of Psychological Medicine, Neuropsychiatric Genetics Unit, University of Wales College of Medicine, Cardiff, CF14 4XN, UK. Williamsnm@cf.ac.uk
Genome Biology
|May 2, 2002
Abstract:
Systematic genome-wide scans to date have shown that genes of major effect are not common causes of schizophrenia, but independent linkage studies looking for schizophrenia susceptibility genes are converging on a number of key chromosomal locations. Microarray expression analysis may identify new candidate genes and pathways, and a number of intriguing preliminary findings have already been reported.