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An unusual two-tailed mouse.

D J Nash

    Teratology
    |October 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A mouse heterozygous for the Bent-tail (Bn) gene exhibited a rare two-tailed malformation. One tail was normal, while the other showed kinks and malformed vertebrae, suggesting a unique genetic event.

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    Area of Science:

    • Developmental biology
    • Genetics
    • Mammalian teratology

    Background:

    • The Bent-tail (Bn) gene is a sex-linked gene in mice known to cause vertebral malformations.
    • Bifurcated tail conditions are rare but documented anomalies in mouse models.
    • Understanding genetic mutations is crucial for studying developmental processes and congenital abnormalities.

    Purpose of the Study:

    • To describe a novel case of a two-tailed mouse.
    • To compare this malformation with existing knowledge of bifurcated tails in mice.
    • To explore the potential genetic mechanisms, specifically X-chromosome inactivation, underlying this condition.

    Main Methods:

    • Phenotypic description of a mouse exhibiting a two-tailed malformation.
    • Detailed morphological analysis of vertebral structure in both tails.

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  • Comparative analysis with literature data on mouse tail malformations and the Bent-tail (Bn) gene.

    • Main Results:

    • A heterozygous mouse for the Bent-tail (Bn) gene presented with two complete tails.
    • One tail was normal (29 vertebrae), while the second exhibited 27 vertebrae with kinks and malformations consistent with the Bn phenotype.
    • The observed malformation shares characteristics with previously reported bifurcated tail conditions.

    Conclusions:

    • The described two-tailed mouse represents a unique manifestation of the Bent-tail (Bn) gene mutation.
    • This case may illustrate a specific instance of X-chromosome inactivation influencing developmental patterning.
    • Further investigation into X-chromosome inactivation mechanisms could provide insights into complex congenital malformations.