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Synthesis and anti-tubercular evaluation of 4-quinolylhydrazones
Luisa Savini1, Luisa Chiasserini, Alessandra Gaeta
1Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy. savini@unisi.it
Bioorganic & Medicinal Chemistry
|May 2, 2002
Abstract:
A series of 4-quinolylhydrazones were synthesized and tested against Mycobacterium tuberculosis H37Rv. Preparation of the title compounds was achieved by reaction of 4-quinolylhydrazine and aryl- or heteroaryl-carboxaldehyde. For the most of derivatives interesting antitubercular properties were showed; two compounds (3(2) and 3(25)), identified as the most active, were tested also against Mycobacterium avium.