Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physical performance and longevity in aged rats.

Christy S Carter1, William E Sonntag, Graziano Onder

  • 1Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. chrcarte@wfubmc.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|May 2, 2002
PubMed
Summary

Physical performance declines with age in rats, similar to humans. Higher baseline scores in aged rats predict longer longevity, suggesting conserved aging mechanisms across species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The immune response to SARS-CoV-2 vaccination in older people.

The lancet. Healthy longevity·2023
Same author

Sex differences in the efficacy and safety of SARS-CoV-2 vaccination in residents of long-term care facilities: insights from the GeroCovid Vax study.

Internal and emergency medicine·2023
Same author

Reply to the Letter "Paracetamol: should we hide it within the NSAID category to dismiss its real infodemiology analysis?"

Aging clinical and experimental research·2023
Same author

Multiomics profiling of the impact of an angiotensin (1-7)-expressing probiotic combined with exercise training in aged male rats.

Journal of applied physiology (Bethesda, Md. : 1985)·2023
Same author

Frailty detection among primary care older patients through the Primary Care Frailty Index (PC-FI).

Scientific reports·2023
Same author

Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study.

Frontiers in medicine·2023

Area of Science:

  • Gerontology
  • Comparative Physiology
  • Animal Models of Aging

Background:

  • Physical performance decline is a hallmark of aging in humans, predicting disability and mortality.
  • Standardized physical performance measures in humans correlate with healthspan and lifespan.
  • Understanding age-related performance decline in animal models can illuminate conserved biological mechanisms.

Purpose of the Study:

  • To longitudinally assess physical performance in aged rats.
  • To determine if performance measures in rats predict longevity.
  • To explore conserved mechanisms of aging between rats and humans.

Main Methods:

  • Longitudinal assessment of physical performance in aged rats (24-30 months old).
  • Measures included swimming speed and an inclined plane procedure.

Related Experiment Videos

  • Correlation analysis between baseline performance scores and longevity.

    • Main Results:

    • Aged rats showed progressive performance decline over a 6-month period.
    • Higher baseline physical performance scores were associated with increased longevity.
    • This relationship mirrors findings observed in human aging studies.

    Conclusions:

    • Standardized physical performance measures are valuable in aged rat models.
    • Performance decline and its link to longevity are conserved aging features.
    • Animal models can help elucidate species-conserved mechanisms of aging.