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Fascia lata valves: a clinicopathological study
Thorax
|October 1, 1975
Summary
Fascia lata cardiac valves showed significant degeneration and reduced activity over time, suggesting they are a poor substitute for diseased valve replacement. Fibrous tissue contraction may lead to valve dysfunction.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
- Histopathology
Background:
- Frame-mounted fascia lata valves were used for cardiac valve replacement.
- Indications for transplantation included chronic rheumatic endocarditis and calcific aortic disease.
Purpose of the Study:
- To histologically evaluate fascia lata valves explanted after 10-44 months.
- To assess the long-term viability and structural integrity of these bioprosthetic valves.
Main Methods:
- Histological examination of 16 explanted fascia lata valves.
- Viability studies were performed on valves from two patients.
Main Results:
- Valves showed progressive degeneration of collagen and decreased fibroblastic nuclei over time.
- Mitral valves exhibited less change in the leaflet nearest the original cusp.
- Explanted valves demonstrated significantly reduced cellular activity.
Conclusions:
- Fascia lata valves undergo structural deterioration, with changes intensifying over time.
- Contraction of surrounding fibrous tissue may impair valve function.
- Fascia lata is concluded to be an inadequate material for cardiac valve replacement.