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Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?
1Cardiac Electrophysiology Laboratories, Departments of Medicine and of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA. foz@hearts.bsd.uchicago.edu
Abstract:
Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassium channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.